flu.org.cn newsletter

OIE: High pathogenicity avian influenza viruses - Togo: poultry
General information Report type: immediate notification Started: 1 Jan 2022 Confirmed: 5 Jan 2022 Reported: 14 Jan 2022 Reason for notification: recurrence ...
submitted by kickingbird at Jan, 19, 2022 11:42 AM via(https://wahis.oie.int/#/report-info?reportId=46660)

China: Four human cases of avian influenza A(H9N2) reported in Mainland
Jiangsu Province(Zhenjiang city):? A 7-year-old girl with onset on November 27, 2021.Hubei Province(Huanggang city):? A 3-year-old girl with onset on December ...
submitted by kickingbird at Jan, 19, 2022 10:14 AM via(https://www.chp.gov.hk/files/pdf/2022_avian_influenza_report_vol18_wk03.pdf)

Article

Pathology and virology of natural highly pathogenic avian influenza H5N8 infection in wild Common buzzards (Buteo buteo)
Highly pathogenic avian influenza (HPAI) in wild birds is a major emerging disease, and a cause of increased mortality during outbreaks. The Common buzzard ...
submitted by kickingbird at Jan, 20, 2022 21:2 PM via(https://www.nature.com/articles/s41598-022-04896-7)

Contribution of RNA-RNA interactions mediated by the genome packaging signals for the selective genome packaging of influenza A virus
The influenza A virus genome is composed of eight single-stranded negative-sense RNA segments (vRNAs). The eight vRNAs are selectively packaged into each ...
submitted by kickingbird at Jan, 20, 2022 21:1 PM via(https://journals.asm.org/doi/10.1128/JVI.01641-21)

The species-specific 282 residue in the PB2 subunit of the polymerase regulates RNA synthesis and replication of influenza A viruses infecting bat and non-bat hosts
Bat influenza viruses are genetically distant from classical influenza A viruses (IAV) and show distinct functional differences in their surface antigens. ...
submitted by kickingbird at Jan, 20, 2022 21:0 PM via(https://journals.asm.org/doi/10.1128/jvi.02190-21)

N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses
Influenza A viruses (IAV) initiate infection by binding to glycans with terminal sialic acids on the cell surface. Hosts of IAV variably express two major ...
submitted by kickingbird at Jan, 20, 2022 20:59 PM via(https://journals.asm.org/doi/10.1128/jvi.02120-21)

KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity
Influenza A virus (IAV) RNA-dependent RNA polymerase (vPol) is a heterotrimer composed of PB2, PB1, and PA, which, together with vRNA and nucleoprotein ...
submitted by kickingbird at Jan, 20, 2022 20:57 PM via(https://journals.asm.org/doi/10.1128/spectrum.02073-21)

Identification of a permissive secondary mutation that restores the enzymatic activity of oseltamivir resistance mutation H275Y
Many oseltamivir resistance mutations exhibit fitness defects in the absence of drug pressure that hinders their propagation in hosts. Secondary permissive ...
submitted by kickingbird at Jan, 20, 2022 20:56 PM via(https://journals.asm.org/doi/10.1128/jvi.01982-21)

Evolution of influenza A virus in intensive and free-range swine farms in Spain
Swine harbor genetically diverse influenza A viruses (IAVs) with the capacity to host-switch to humans, causing global pandemics. Spain is the largest ...
submitted by kickingbird at Jan, 19, 2022 10:6 AM via(https://academic.oup.com/ve/article/7/2/veab099/6446465)

Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza
Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic influenza. ...
submitted by kickingbird at Jan, 19, 2022 10:5 AM via(https://jlb.onlinelibrary.wiley.com/doi/10.1002/JLB.6A1021-535R)

Epidemiology and direct healthcare costs of Influenza-associated hospitalizations - nationwide inpatient data (Germany 2010-2019)
Introduction: Detailed and up-to-date data on the epidemiology and healthcare costs of Influenza are fundamental for public health decision-making. We ...
submitted by kickingbird at Jan, 18, 2022 14:6 PM via(https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-022-12505-5)

Sequence characteristics and phylogenetic analysis of H9N2 subtype avian influenza A viruses detected from poultry and the environment in China, 2018
H9N2 subtype avian influenza A virus (AIV) is a causative agent that poses serious threats to both the poultry industry and global public health. In this ...
submitted by kickingbird at Jan, 18, 2022 14:3 PM via(https://peerj.com/articles/12512/)

Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus
Background: The first and only case of human infection with the avian influenza A (H7N4) virus in China emerged in 2018. The H7N4 virus was distinct from ...
submitted by kickingbird at Jan, 18, 2022 14:2 PM via(https://onlinelibrary.wiley.com/doi/10.1111/irv.12954)

Benefit-cost analysis of a H7N9 vaccination program in poultry in Guangxi, China
China launched a H7N9 vaccination program in poultry, starting from the Guangxi and Guangdong provinces in July 2017, followed by other provinces in September ...
submitted by kickingbird at Jan, 17, 2022 10:4 AM via(https://www.sciencedirect.com/science/article/abs/pii/S0167587722000137)