flu.org.cn newsletter

OIE: Influenza A viruses of high pathogenicity (Infection with H5N1) (non-poultry including wild birds) (2017-), Germany
Summary Report type: immediate notification Started: 4 Jan 2022 Confirmed: 7 Jan 2022 Reported: 12 Jan 2022 Reason for notification: new strain in a zone ...
submitted by kickingbird at Jan, 14, 2022 7:25 AM via(https://wahis.oie.int/#/report-info?reportId=46397)

OIE: Influenza A viruses of high pathogenicity (Infection with H5N1) (non-poultry including wild birds) (2017-), Germany
Summary Report type: immediate notification Started: 30 Dec 2021 Confirmed: 31 Dec 2021 Reported: 11 Jan 2022 Reason for notification: 1st occurrence in ...
submitted by kickingbird at Jan, 14, 2022 7:24 AM via(https://wahis.oie.int/#/report-info?reportId=46271)

China: CHP closely monitors five human cases of avian influenza A(H5N6) in Mainland
The Centre for Health Protection (CHP) of the Department of Health is (January 13) closely monitoring five human cases of avian influenza A(H5N6) in the ...
submitted by kickingbird at Jan, 14, 2022 7:11 AM via(https://www.info.gov.hk/gia/general/202201/13/P2022011300628.htm)

Article

In silico analysis of local RNA secondary structure in influenza virus A, B and C finds evidence of widespread ordered stability but little evidence of significant covariation
Influenza virus is a persistent threat to human health; indeed, the deadliest modern pandemic was in 1918 when an H1N1 virus killed an estimated 50 million ...
submitted by kickingbird at Jan, 13, 2022 8:45 AM via(https://www.nature.com/articles/s41598-021-03767-x)

Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation
Background: Several countries have recently transitioned from the trivalent inactivated influenza vaccine (TIV) to the quadrivalent inactivated influenza ...
submitted by kickingbird at Jan, 13, 2022 8:43 AM via(https://www.sciencedirect.com/science/article/pii/S0264410X21016649)

Incidence, circulation, and spatiotemporal analysis of seasonal influenza in Shandong, China, 2008-2019: A retrospective study
Background: Understanding the influenza-like illness (ILI) incidence, circulation pattern of virus strains and spatiotemporal pattern of influenza transmission ...
submitted by kickingbird at Jan, 13, 2022 8:41 AM via(https://onlinelibrary.wiley.com/doi/10.1111/irv.12959)

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and a zoonotic potential
An H7N9 low pathogenicity avian influenza virus (LPAIV) emerged in 2013 through genetic reassortment between H9N2 and other LPAIVs circulating in birds ...
submitted by kickingbird at Jan, 13, 2022 8:40 AM via(https://journals.asm.org/doi/10.1128/jvi.01856-21)

The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a
Influenza A virus (IAV) contains a segmented RNA genome that is transcribed and replicated by the viral RNA polymerase in the cell nucleus. Replicated ...
submitted by kickingbird at Jan, 13, 2022 8:38 AM via(https://journals.asm.org/doi/10.1128/jvi.01979-21)

Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response
Influenza A virus (IAV), an obligatory intracellular parasite, uses host cellular molecules to complete its replication cycle and suppress immune responses. ...
submitted by kickingbird at Jan, 13, 2022 8:37 AM via(https://journals.asm.org/doi/10.1128/jvi.01990-21)

Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China
The H9N2 subtype avian influenza virus (AIV) has become endemic in poultry globally; however due to its low pathogenicity, it is not under primary surveillance ...
submitted by kickingbird at Jan, 13, 2022 8:36 AM via(https://journals.asm.org/doi/10.1128/spectrum.00822-21)

Characterization of a 2016-2017 Human Seasonal H3 Influenza A Virus Spillover Now Endemic to U.S. Swine
In 2017, the Iowa State University Veterinary Diagnostic Laboratory detected a reverse-zoonotic transmission of a human seasonal H3 influenza A virus into ...
submitted by kickingbird at Jan, 13, 2022 8:35 AM via(https://journals.asm.org/doi/10.1128/msphere.00809-21)

Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies
Influenza A viruses cause seasonal epidemics and global pandemics, representing a considerable burden to healthcare systems. Central to the replication ...
submitted by kickingbird at Jan, 13, 2022 8:33 AM via(https://www.nature.com/articles/s41467-021-27950-w)

A Systematic Review of Influenza Epidemiology and Surveillance in the Eastern Mediterranean and North African Region
Seasonal influenza represents a huge health burden, resulting in significant mortality and morbidity. Following the 2009 H1N1 pandemic, focus has been ...
submitted by kickingbird at Jan, 10, 2022 7:47 AM via(https://link.springer.com/article/10.1007%2Fs40121-021-00534-3)

The highly pathogenic H5N1 avian influenza virus induces the MAPK signaling pathway in the trachea of two Ri chicken lines
Objective: The highly pathogenic avian influenza virus (HPAIV) is a threat to the poultry industry and economy and remains a potential source of pandemic ...
submitted by kickingbird at Jan, 10, 2022 7:45 AM via(https://www.animbiosci.org/journal/view.php?doi=10.5713/ab.21.0420)

Selective dependence on IL-7 for antigen-specific CD8 T cell responses during airway influenza infection
Interleukin-7 (IL-7) is a cytokine known for its importance in T cell development and survival. How IL-7 shapes CD8 T cell responses during an acute viral ...
submitted by kickingbird at Jan, 10, 2022 7:44 AM via(https://www.nature.com/articles/s41598-021-03936-y)

Association between plasma glycocalyx component levels and poor prognosis in severe influenza type A (H1N1)
Influenza A virus infection causes a series of diseases, but the factors associated with disease severity are not fully understood. Disruption of the endothelial ...
submitted by kickingbird at Jan, 10, 2022 7:43 AM via(https://www.nature.com/articles/s41598-021-04146-2)

Estimation of Avian Influenza Viruses in Water Environments of Live Poultry Markets in Changsha, China, 2014 to 2018
In routine surveillance for avian influenza viruses (AIVs) in the environments of live poultry markets (LPMs), certain samples were positive for AIVs type ...
submitted by kickingbird at Jan, 10, 2022 7:42 AM via(https://link.springer.com/article/10.1007%2Fs12560-021-09506-9)